“Ovulation results in a mid-cycle surge of luteinizing hormone (LH) followed by an increase in progesterone secretion, peaking between day 21 and 23. If no fertilization and implantation has occurred by then, supplying the corpus luteum with human gonadotropin-drive growth stimulus, progesterone secretion falls, ultimately triggering menstruation.
Read MoreOvulation results in a mid-cycle surge of luteinizing hormone (LH) followed by an increase in progesterone secretion, peaking between day 21 and 23. If no fertilization and implantation has occurred by then, supplying the corpus luteum with human gonadotropin-drive growth stimulus, progesterone secretion falls, ultimately triggering menstruation.
Read MoreOf the three major estrogens (estrone [e1], estradiol [e2], estriol [e3]), is the least potent natural estrogen (E2 > E1 > E3). In men and non-pregnant women, E1 and E2 are formed from androstenedione and testosterone. E3 is synthesized from E2 and to a limited extent, from 16-alpha metabolites of estrone.
Read MoreEstrone is one of two major estrogens in non-pregnant women and is a major estrogen produced by the placenta.22 The primary ovarian estrogen is estradiol; circulating estrone is derived from ovarian secretion and peripheral conversion from gonadal and adrenal androstenedione (via CYP450 aromatase in lipid tissue)
Read MoreDHT has been called the “principal prostatic androgen.”36 Levels of this hormone remain fairly constant with age, in spite of a decrease in plasma testosterone. The levels of this hormone are not elevated in benign prostatic hyperplasia (BPH).
Read MoreConcentrations of DHEA peak around age 30 and decline with age. The serum values have a circadian variation, and may vary during the menstrual cycle, which prompts some to suggest that DHEA-S to be a better clinical marker (longer half-life, no circadian variation)
Read MoreElevated serum levels of this hormone are important in only a few diseases that involve enzymatic deficiencies, generalized adrenal hyperfunction, or direct adrenal tumor production, such as congenital adrenal hyperplasia due to CYP11B1 and 17alpha-hydroxylase deficiencies.
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