11-deoxycortisol AND 21-deoxycortisol Hormones

 

11-deoxycortisol

Reference Range:

Reference Range:

Reference Ranges“The differential biochemical diagnosis of congenital adrenal hyperplasia caused by 11-β-hydroxylase deficiency includes finding increased serum concentrations of deoxycorticosterone, 11-desoxycortisol and androstenedione, and suppre…

Reference Ranges

“The differential biochemical diagnosis of congenital adrenal hyperplasia caused by 11-β-hydroxylase deficiency includes finding increased serum concentrations of deoxycorticosterone, 11-desoxycortisol and androstenedione, and suppressed plasma renin concentrations. The disorder may be treated by administration of glucocorticoids. An additional use is to evaluate hypothalamic-pituitary-adrenal axis and pituitary ACTH reserve. 11-deoxycortisol is the immediate precursor of cortisol and follows the same catabolic pathways as cortisol.

This test is often used to evaluate the “hypothalamic-pituitary-adrenal axis and pituitary ACTH reserve. 11-deoxycortisol is the immediate precursor and follows the same catabolic pathways as cortisol.  This test can also be used to diagnose congenital adrenal hyperplasia (CAH), an inherited/genetic condition caused by deficiency in the CYP11B1 gene (for 11-beta-hydroxylase). The deficiency is an autosomal recessive trait, associated with low-renin hypertension, hypokalemia, excess androgens (androstenedione, especially), and genital ambiguity in females.

Additional Values

Additional Values

21-deoxycortisol

Serum Values

Serum Values

 
hormonesClinicore11-deoxycortisol, diagnostic testing, hormones